InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: RPH3AL

Summary

InnateDB Protein

IDBP-684292.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPH3AL

Protein Name

Rab effector Noc2

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000050227

InnateDB Gene

IDBG-632666 (RPH3AL)

Protein Structure

UniProt Annotation

Function

Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0017137	Rab GTPase binding
GO:0046872	metal ion binding

Biological Process

GO:0006886	intracellular protein transport
GO:0006887	exocytosis
GO:0017158	regulation of calcium ion-dependent exocytosis
GO:0042593	glucose homeostasis
GO:0045744	negative regulation of G-protein coupled receptor protein signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0016020	membrane
GO:0030658	transport vesicle membrane
GO:0031410	cytoplasmic vesicle

Protein Structure and Domains

PDB ID

InterPro

IPR010911 Zinc finger, FYVE-type
IPR011011 Zinc finger, FYVE/PHD-type
IPR017455 Zinc finger, FYVE-related

PFAM

PF02318

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC102095 BT021718 DAAA02048654 DAAA02048655 DAAA02048656

GenPept

AAI02096 AAX46565

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1)

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca