Version 5.4
Bos taurus Gene: RPH3AL
Summary
InnateDB Gene IDBG-632666.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RPH3AL
Gene Name Rab effector Noc2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000039819
Encoded Proteins
IDBP-684292
Rab effector Noc2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000181031:
The protein encoded by this gene plays a direct regulatory role in calcium-ion-dependent exocytosis in both endocrine and exocrine cells and plays a key role in insulin secretion by pancreatic cells. This gene is likely a tumor suppressor. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:22872042-23011338
Strand Forward strand
Band
Transcripts
ENSBTAT00000052707 ENSBTAP00000050227
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017137 Rab GTPase binding
GO:0046872 metal ion binding
Biological Process
GO:0006886 intracellular protein transport
GO:0006887 exocytosis
GO:0017158 regulation of calcium ion-dependent exocytosis
GO:0042593 glucose homeostasis
GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0030658 transport vesicle membrane
GO:0031410 cytoplasmic vesicle
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000181031
View Gene Order
ENSMUSG00000020847
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.25326
RefSeq NM_001035494
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca