InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: FBXO2

Summary

InnateDB Protein

IDBP-684331.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FBXO2

Protein Name

F-box only protein 2

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000009501

InnateDB Gene

IDBG-632697 (FBXO2)

Protein Structure

UniProt Annotation

Function

Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Microsome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006516	glycoprotein catabolic process
GO:0016567	protein ubiquitination
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0016020	membrane
GO:0019005	SCF ubiquitin ligase complex
GO:0031090	organelle membrane
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR001810 F-box domain
IPR007397 F-box associated (FBA) domain
IPR008979 Galactose-binding domain-like

PFAM

PF00646
PF12937
PF13013
PF04300

PRINTS

PIRSF

SMART

SM00256

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q17QK6

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

512589

UniGene

Bt.88141

RefSeq

NP_001069037

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC118302

GenPept

AAI18303