InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: FBXO2

Summary

InnateDB Gene

IDBG-632697.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FBXO2

Gene Name

F-box only protein 2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000007223

Encoded Proteins

IDBP-684331

F-box only protein 2

IDBP-684338

F-box only protein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116661:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is highly similar to the rat NFB42 (neural F Box 42 kDa) protein which is enriched in the nervous system and may play a role in maintaining neurons in a postmitotic state. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:42906700-42912737

Strand

Forward strand

Band

Transcripts

ENSBTAT00000009501	ENSBTAP00000009501
ENSBTAT00000054333	ENSBTAP00000048374

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001540	beta-amyloid binding
GO:0001948	glycoprotein binding
GO:0005515	protein binding
GO:0030246	carbohydrate binding

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006516	glycoprotein catabolic process
GO:0016567	protein ubiquitination
GO:0030433	ER-associated ubiquitin-dependent protein catabolic process
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031396	regulation of protein ubiquitination

Cellular Component

GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0016020	membrane
GO:0019005	SCF ubiquitin ligase complex
GO:0031090	organelle membrane
GO:0043197	dendritic spine
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome