InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CAV2

Summary

InnateDB Protein

IDBP-684493.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CAV2

Protein Name

Caveolin-2

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000054207

InnateDB Gene

IDBG-632838 (CAV2)

Protein Structure

UniProt Annotation

Function

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:15370296}. Cytoplasm {ECO:0000269PubMed:15370296}. Golgi apparatus membrane {ECO:0000269PubMed:15370296}; Peripheral membrane protein {ECO:0000269PubMed:15370296}. Cell membrane {ECO:0000269PubMed:15370296}; Peripheral membrane protein {ECO:0000269PubMed:15370296}. Membrane, caveola {ECO:0000269PubMed:15370296}; Peripheral membrane protein {ECO:0000269PubMed:15370296}. Note=Potential hairpin-like structure in the membrane. Membrane protein of caveolae. Tyr-19- phosphorylated form is enriched at sites of cell-cell contact and is translocated to the nucleus in complex with MAPK1 in response to insulin. Tyr-27-phosphorylated form is located both in the cytoplasm and plasma membrane. CAV1-mediated Ser-23-phosphorylated form locates to the plasma membrane. Ser-36-phosphorylated form resides in intracellular compartments (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in aortic endothelial cells. {ECO:0000269PubMed:15370296}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0031748	D1 dopamine receptor binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0001937	negative regulation of endothelial cell proliferation
GO:0001938	positive regulation of endothelial cell proliferation
GO:0006906	vesicle fusion
GO:0007005	mitochondrion organization
GO:0007029	endoplasmic reticulum organization
GO:0007088	regulation of mitosis
GO:0008285	negative regulation of cell proliferation
GO:0016050	vesicle organization
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0048278	vesicle docking
GO:0048741	skeletal muscle fiber development
GO:0051259	protein oligomerization
GO:0060161	positive regulation of dopamine receptor signaling pathway
GO:0070836	caveola assembly

Cellular Component

GO:0000139	Golgi membrane
GO:0002080	acrosomal membrane
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005901	caveola
GO:0016020	membrane
GO:0030133	transport vesicle
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
GO:0031410	cytoplasmic vesicle
GO:0042383	sarcolemma
GO:0043234	protein complex
GO:0045121	membrane raft
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001612 Caveolin

PFAM

PF01146

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q66WT7

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

493642

UniGene

Bt.111373

RefSeq

NP_001007809

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AY699947 BC134620 DP000008

GenPept

AAI34621 AAR16255 AAU05317