InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CAV2

Summary

InnateDB Gene

IDBG-632838.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CAV2

Gene Name

Caveolin-2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000045584

Encoded Proteins

IDBP-684493

Caveolin-2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105971:
The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. This gene and related family member (CAV1) are located next to each other on chromosome 7, and express colocalizing proteins that form a stable hetero-oligomeric complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Additional isoforms resulting from the use of alternate in-frame translation initiation codons have also been described, and shown to have preferential localization in the cell (PMID:11238462). [provided by RefSeq, May 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:52230674-52235915

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000064292

ENSBTAP00000054207

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0031748	D1 dopamine receptor binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0001937	negative regulation of endothelial cell proliferation
GO:0001938	positive regulation of endothelial cell proliferation
GO:0006906	vesicle fusion
GO:0007005	mitochondrion organization
GO:0007029	endoplasmic reticulum organization
GO:0007088	regulation of mitosis
GO:0008285	negative regulation of cell proliferation
GO:0016050	vesicle organization
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0048278	vesicle docking
GO:0048741	skeletal muscle fiber development
GO:0051259	protein oligomerization
GO:0060161	positive regulation of dopamine receptor signaling pathway
GO:0070836	caveola assembly

Cellular Component

GO:0000139	Golgi membrane
GO:0002080	acrosomal membrane
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005901	caveola
GO:0016020	membrane
GO:0030133	transport vesicle
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
GO:0031410	cytoplasmic vesicle
GO:0042383	sarcolemma
GO:0043234	protein complex
GO:0045121	membrane raft
GO:0048471	perinuclear region of cytoplasm