InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: SLC8A1

Summary

InnateDB Protein

IDBP-684511.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC8A1

Protein Name

sodium/calcium exchanger 1 precursor

Synonyms

NCX1;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000022795

InnateDB Gene

IDBG-632844 (SLC8A1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005432	calcium:sodium antiporter activity
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding

Biological Process

GO:0001892	embryonic placenta development
GO:0002026	regulation of the force of heart contraction
GO:0003007	heart morphogenesis
GO:0006814	sodium ion transport
GO:0006816	calcium ion transport
GO:0007154	cell communication
GO:0009791	post-embryonic development
GO:0034614	cellular response to reactive oxygen species
GO:0035050	embryonic heart tube development
GO:0048747	muscle fiber development
GO:0055013	cardiac muscle cell development
GO:0055085	transmembrane transport
GO:0060048	cardiac muscle contraction
GO:0070509	calcium ion import
GO:0071436	sodium ion export
GO:0097369	sodium ion import
GO:1901660	calcium ion export

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0030315	T-tubule
GO:0042383	sarcolemma

Protein Structure and Domains

PDB ID

InterPro

IPR001623 DnaJ domain
IPR002987 Sodium/calcium exchanger, isoform 1
IPR003644 Na-Ca exchanger/integrin-beta4
IPR004836 Sodium/calcium exchanger protein
IPR004837 Sodium/calcium exchanger membrane region

PFAM

PF00226
PF03160
PF01699

PRINTS

PR00625
PR01260
PR01259

PIRSF

SMART

SM00271
SM00237

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt