InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SLC8A1

Summary

InnateDB Gene

IDBG-632844.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC8A1

Gene Name

sodium/calcium exchanger 1 precursor

Synonyms

NCX1

Species

Bos taurus

Ensembl Gene

ENSBTAG00000013861

Encoded Proteins

IDBP-684511

sodium/calcium exchanger 1 precursor

IDBP-684513

sodium/calcium exchanger 1 precursor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000183023:
In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.[supplied by OMIM, Apr 2004]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:22443220-22797877

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000022795	ENSBTAP00000022795
ENSBTAT00000018452	ENSBTAP00000018452

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005432	calcium:sodium antiporter activity
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding

Biological Process

GO:0001892	embryonic placenta development
GO:0002026	regulation of the force of heart contraction
GO:0003007	heart morphogenesis
GO:0006814	sodium ion transport
GO:0006816	calcium ion transport
GO:0007154	cell communication
GO:0009791	post-embryonic development
GO:0034614	cellular response to reactive oxygen species
GO:0035050	embryonic heart tube development
GO:0035725	sodium ion transmembrane transport
GO:0048747	muscle fiber development
GO:0055013	cardiac muscle cell development
GO:0055085	transmembrane transport
GO:0060048	cardiac muscle contraction
GO:0070509	calcium ion import
GO:0071436	sodium ion export
GO:0097369	sodium ion import
GO:1901660	calcium ion export

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0030315	T-tubule
GO:0042383	sarcolemma