Version 5.4
Bos taurus Protein: SERPINF2
Summary
InnateDB Protein IDBP-684557.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SERPINF2
Protein Name Alpha-2-antiplasmin
Synonyms PLI;
Species Bos taurus
Ensembl Protein ENSBTAP00000027793
InnateDB Gene IDBG-632888 (SERPINF2)
Protein Structure
UniProt Annotation
Function Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin (By similarity). {ECO:0000250}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Expressed by the liver and secreted in plasma.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005515 protein binding
GO:0030414 peptidase inhibitor activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0002034 regulation of blood vessel size by renin-angiotensin
GO:0006953 acute-phase response
GO:0010466 negative regulation of peptidase activity
GO:0010757 negative regulation of plasminogen activation
GO:0010951 negative regulation of endopeptidase activity
GO:0030162 regulation of proteolysis
GO:0030199 collagen fibril organization
GO:0032967 positive regulation of collagen biosynthetic process
GO:0045597 positive regulation of cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046330 positive regulation of JNK cascade
GO:0048514 blood vessel morphogenesis
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0051496 positive regulation of stress fiber assembly
GO:0051918 negative regulation of fibrinolysis
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071636 positive regulation of transforming growth factor beta production
Cellular Component
GO:0005576 extracellular region
GO:0005577 fibrinogen complex
GO:0005615 extracellular space
GO:0009986 cell surface
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Protein Structure and Domains
PDB ID
InterPro IPR023796 Serpin domain
PFAM PF00079
PRINTS
PIRSF
SMART SM00093
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P28800
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 282522
UniGene Bt.9352
RefSeq NP_777095
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL X78436
GenPept CAA55200

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca