InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SERPINF2

Summary

InnateDB Gene

IDBG-632888.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SERPINF2

Gene Name

Alpha-2-antiplasmin

Synonyms

PLI

Species

Bos taurus

Ensembl Gene

ENSBTAG00000020859

Encoded Proteins

IDBP-684557

Alpha-2-antiplasmin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167711:
This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:23403657-23411269

Strand

Forward strand

Band

Transcripts

ENSBTAT00000027793

ENSBTAP00000027793

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005515	protein binding
GO:0030414	peptidase inhibitor activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0002034	regulation of blood vessel size by renin-angiotensin
GO:0006953	acute-phase response
GO:0010466	negative regulation of peptidase activity
GO:0010757	negative regulation of plasminogen activation
GO:0010951	negative regulation of endopeptidase activity
GO:0030162	regulation of proteolysis
GO:0030199	collagen fibril organization
GO:0032967	positive regulation of collagen biosynthetic process
GO:0045597	positive regulation of cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046330	positive regulation of JNK cascade
GO:0048514	blood vessel morphogenesis
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0051496	positive regulation of stress fiber assembly
GO:0051918	negative regulation of fibrinolysis
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0071636	positive regulation of transforming growth factor beta production

Cellular Component

GO:0005576	extracellular region
GO:0005577	fibrinogen complex
GO:0005615	extracellular space
GO:0009986	cell surface
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle