Version 5.4
Bos taurus Protein: PTH
Summary
InnateDB Protein IDBP-684617.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTH
Protein Name Parathyroid hormone
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000025399
InnateDB Gene IDBG-632953 (PTH)
Protein Structure
UniProt Annotation
Function PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2- deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity). {ECO:0000250}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005179 hormone activity
GO:0051428 peptide hormone receptor binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006874 cellular calcium ion homeostasis
GO:0009967 positive regulation of signal transduction
GO:0010468 regulation of gene expression
GO:0030501 positive regulation of bone mineralization
GO:0030819 positive regulation of cAMP biosynthetic process
GO:0034645 cellular macromolecule biosynthetic process
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046326 positive regulation of glucose import
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro IPR001415 Parathyroid hormone/parathyroid hormone-related protein
IPR003625 Parathyroid hormone
PFAM PF01279
PRINTS
PIRSF PIRSF001832
SMART SM00087
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P01268
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 280903
UniGene Bt.95
RefSeq NP_776379
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL J00024 K01938 M25082 V00106
GenPept AAA30747 AAA30748 AAA30749 CAA23439

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca