InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: THEMIS

Summary

InnateDB Protein

IDBP-684618.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

THEMIS

Protein Name

Protein THEMIS

Synonyms

C9H6ORF190; TSEPA;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000020742

InnateDB Gene

IDBG-632941 (THEMIS)

Protein Structure

UniProt Annotation

Function

Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0002376	immune system process
GO:0007275	multicellular organismal development
GO:0043368	positive T cell selection
GO:0043383	negative T cell selection
GO:0050852	T cell receptor signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005911	cell-cell junction
GO:0008180	COP9 signalosome

Protein Structure and Domains

PDB ID

InterPro

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A5D789

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

540554

UniGene

Bt.87738

RefSeq

NP_001091585

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC140469 BC149610

GenPept

AAI40470 AAI49611