Version 5.4
Bos taurus Gene: THEMIS
Summary
InnateDB Gene IDBG-632941.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol THEMIS
Gene Name Protein THEMIS
Synonyms C9H6ORF190; TSEPA
Species Bos taurus
Ensembl Gene ENSBTAG00000015615
Encoded Proteins
IDBP-684618
Protein THEMIS
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000172673:
This gene encodes a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:66683790-66885925
Strand Reverse strand
Band
Transcripts
ENSBTAT00000020742 ENSBTAP00000020742
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0002376 immune system process
GO:0007275 multicellular organismal development
GO:0043368 positive T cell selection
GO:0043383 negative T cell selection
GO:0050852 T cell receptor signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005911 cell-cell junction
GO:0008180 COP9 signalosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000172673
View Gene Order
ENSMUSG00000049109
View Gene Order
Cross-References
SwissProt A5D789
TrEMBL
UniProt Splice Variant
Entrez Gene 540554
UniGene Bt.87738
RefSeq NM_001098116
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC140469 BC149610
GenPept AAI40470 AAI49611
RNA Seq Atlas 540554

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca