InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CLASP1

Summary

InnateDB Protein

IDBP-68463.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLASP1

Protein Name

cytoplasmic linker associated protein 1

Synonyms

MAST1;

Species

Homo sapiens

Ensembl Protein

ENSP00000263710

InnateDB Gene

IDBG-68461 (CLASP1)

Protein Structure

UniProt Annotation

Function

Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. {ECO:0000269PubMed:11290329, ECO:0000269PubMed:12837247, ECO:0000269PubMed:15631994, ECO:0000269PubMed:16866869, ECO:0000269PubMed:16914514, ECO:0000269PubMed:17543864}.

Subcellular Localization

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Golgi apparatus, trans-Golgi network {ECO:0000305}. Note=Localizes to microtubule plus ends. Localizes to centrosomes, kinetochores and the mitotic spindle from prometaphase. Subsequently localizes to the spindle midzone from anaphase and to the midbody from telophase. In migrating cells localizes to the plus ends of microtubules within the cell body and to the entire microtubule lattice within the lamella. Localizes to the cell cortex and this requires ERC1 and PHLDB2.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0043515	kinetochore binding
GO:0051010	microtubule plus-end binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000226	microtubule cytoskeleton organization
GO:0000278	mitotic cell cycle
GO:0001578	microtubule bundle formation
GO:0007020	microtubule nucleation
GO:0007026	negative regulation of microtubule depolymerization
GO:0007163	establishment or maintenance of cell polarity
GO:0007411	axon guidance
GO:0010458	exit from mitosis
GO:0031023	microtubule organizing center organization
GO:0031111	negative regulation of microtubule polymerization or depolymerization
GO:0034453	microtubule anchoring
GO:0051294	establishment of spindle orientation
GO:0051301	cell division

Cellular Component

GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0005794	Golgi apparatus
GO:0005813	centrosome
GO:0005828	kinetochore microtubule
GO:0005829	cytosol
GO:0005876	spindle microtubule
GO:0005881	cytoplasmic microtubule
GO:0005938	cell cortex
GO:0016020	membrane
GO:0030981	cortical microtubule cytoskeleton
GO:0031592	centrosomal corona
GO:0070062	extracellular vesicular exosome