InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CLASP1

Summary

InnateDB Gene

IDBG-68461.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLASP1

Gene Name

cytoplasmic linker associated protein 1

Synonyms

MAST1

Species

Homo sapiens

Ensembl Gene

ENSG00000074054

Encoded Proteins

IDBP-68463

cytoplasmic linker associated protein 1

IDBP-234984

cytoplasmic linker associated protein 1

IDBP-294422

cytoplasmic linker associated protein 1

IDBP-385357

cytoplasmic linker associated protein 1

IDBP-385358

cytoplasmic linker associated protein 1

IDBP-385360

cytoplasmic linker associated protein 1

IDBP-385362

cytoplasmic linker associated protein 1

IDBP-597243

cytoplasmic linker associated protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

CLASPs, such as CLASP1, are nonmotor microtubule-associated proteins that interact with CLIPs (e.g., CLIP170; MIM 179838). CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the spindle (Maiato et al., 2003 [PubMed 12837247]).[supplied by OMIM, Mar 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:121337776-121649587

Strand

Reverse strand

Band

q14.3

Transcripts

ENST00000263710	ENSP00000263710
ENST00000397587	ENSP00000380717
ENST00000409078	ENSP00000386442
ENST00000455322	ENSP00000389372
ENST00000452274	ENSP00000400562
ENST00000430234
ENST00000418989	ENSP00000392886
ENST00000449975	ENSP00000402101
ENST00000472776
ENST00000463621
ENST00000491646
ENST00000474065
ENST00000480007
ENST00000485112
ENST00000541377	ENSP00000441625

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0043515	kinetochore binding
GO:0051010	microtubule plus-end binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000226	microtubule cytoskeleton organization
GO:0000278	mitotic cell cycle
GO:0001578	microtubule bundle formation
GO:0007020	microtubule nucleation
GO:0007026	negative regulation of microtubule depolymerization
GO:0007163	establishment or maintenance of cell polarity
GO:0007411	axon guidance
GO:0010458	exit from mitosis
GO:0031023	microtubule organizing center organization
GO:0031111	negative regulation of microtubule polymerization or depolymerization
GO:0034453	microtubule anchoring
GO:0051294	establishment of spindle orientation
GO:0051301	cell division

Cellular Component

GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0005794	Golgi apparatus
GO:0005813	centrosome
GO:0005828	kinetochore microtubule
GO:0005829	cytosol
GO:0005876	spindle microtubule
GO:0005881	cytoplasmic microtubule
GO:0005938	cell cortex
GO:0016020	membrane
GO:0030981	cortical microtubule cytoskeleton
GO:0031592	centrosomal corona
GO:0070062	extracellular vesicular exosome