Version 5.4
Bos taurus Protein: P2RX4
Summary
InnateDB Protein IDBP-684706.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol P2RX4
Protein Name P2X purinoceptor 4
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000014321
InnateDB Gene IDBG-633036 (P2RX4)
Protein Structure
UniProt Annotation
Function Receptor for ATP that acts as a ligand-gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin (By similarity). {ECO:0000250}.
Subcellular Localization Membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001614 purinergic nucleotide receptor activity
GO:0004931 extracellular ATP-gated cation channel activity
GO:0005216 ion channel activity
GO:0005524 ATP binding
GO:0045296 cadherin binding
Biological Process
GO:0006809 nitric oxide biosynthetic process
GO:0006810 transport
GO:0006811 ion transport
GO:0006812 cation transport
GO:0006816 calcium ion transport
GO:0007165 signal transduction
GO:0008217 regulation of blood pressure
GO:0010524 positive regulation of calcium ion transport into cytosol
GO:0010614 negative regulation of cardiac muscle hypertrophy
GO:0033198 response to ATP
GO:0034220 ion transmembrane transport
GO:0034405 response to fluid shear stress
GO:0035590 purinergic nucleotide receptor signaling pathway
GO:0042311 vasodilation
GO:0050850 positive regulation of calcium-mediated signaling
GO:0051899 membrane depolarization
GO:0055117 regulation of cardiac muscle contraction
GO:0055119 relaxation of cardiac muscle
GO:0060079 regulation of excitatory postsynaptic membrane potential
GO:0071318 cellular response to ATP
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0005639 integral component of nuclear inner membrane
GO:0005765 lysosomal membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0045177 apical part of cell
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001429 P2X purinoreceptor
IPR003044 P2X1 purinoceptor
IPR003047 P2X4 purinoceptor
PFAM PF00864
PRINTS PR01307
PR01308
PR01311
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5E9U1
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 338036
UniGene Bt.15997
RefSeq NP_001029221
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC120340 BT020829
GenPept AAI20341 AAX08846

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca