InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: P2RX4

Summary

InnateDB Gene

IDBG-633036.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

P2RX4

Gene Name

P2X purinoceptor 4

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000010812

Encoded Proteins

IDBP-684706

P2X purinoceptor 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135124:
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants, some protein-coding and some not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:56173049-56189197

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000014321

ENSBTAP00000014321

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001614	purinergic nucleotide receptor activity
GO:0004931	extracellular ATP-gated cation channel activity
GO:0005216	ion channel activity
GO:0005524	ATP binding
GO:0045296	cadherin binding

Biological Process

GO:0006809	nitric oxide biosynthetic process
GO:0006810	transport
GO:0006811	ion transport
GO:0006812	cation transport
GO:0006816	calcium ion transport
GO:0007165	signal transduction
GO:0008217	regulation of blood pressure
GO:0010524	positive regulation of calcium ion transport into cytosol
GO:0010614	negative regulation of cardiac muscle hypertrophy
GO:0033198	response to ATP
GO:0034220	ion transmembrane transport
GO:0034405	response to fluid shear stress
GO:0035590	purinergic nucleotide receptor signaling pathway
GO:0042311	vasodilation
GO:0050850	positive regulation of calcium-mediated signaling
GO:0051899	membrane depolarization
GO:0055117	regulation of cardiac muscle contraction
GO:0055119	relaxation of cardiac muscle
GO:0060079	regulation of excitatory postsynaptic membrane potential
GO:0071318	cellular response to ATP
GO:0097190	apoptotic signaling pathway

Cellular Component

GO:0005639	integral component of nuclear inner membrane
GO:0005765	lysosomal membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0045177	apical part of cell
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000135124

View Gene Order

ENSMUSG00000029470

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04080

Neuroactive ligand-receptor interaction pathway

hsa04020

Calcium signaling pathway pathway

mmu04020

Calcium signaling pathway pathway

mmu04080

Neuroactive ligand-receptor interaction pathway

INOH

PID NCI

Cross-References

SwissProt

Q5E9U1

TrEMBL

UniProt Splice Variant

Entrez Gene

338036

UniGene

Bt.15997

RefSeq

NM_001034049 XM_005217747

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC120340 BT020829

GenPept

AAI20341 AAX08846

RNA Seq Atlas

338036