InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: EXOSC10

Summary

InnateDB Protein

IDBP-684707.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EXOSC10

Protein Name

exosome component 10

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000003354

InnateDB Gene

IDBG-632920 (EXOSC10)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 56 interaction(s) predicted by orthology.

Predicted by orthology
Total	56 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003824	catalytic activity
GO:0004532	exoribonuclease activity
GO:0005515	protein binding
GO:0008408	3'-5' exonuclease activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000460	maturation of 5.8S rRNA
GO:0000956	nuclear-transcribed mRNA catabolic process
GO:0006139	nucleobase-containing compound metabolic process
GO:0006396	RNA processing
GO:0009048	dosage compensation by inactivation of X chromosome
GO:0044237	cellular metabolic process
GO:0071028	nuclear mRNA surveillance
GO:0071034	CUT catabolic process
GO:0071035	nuclear polyadenylation-dependent rRNA catabolic process
GO:0071044	histone mRNA catabolic process
GO:0071048	nuclear retention of unspliced pre-mRNA at the site of transcription
GO:0090305	nucleic acid phosphodiester bond hydrolysis
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic

Cellular Component

GO:0000176	nuclear exosome (RNase complex)
GO:0000178	exosome (RNase complex)
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0035327	transcriptionally active chromatin

Protein Structure and Domains

PDB ID

InterPro

IPR002121 HRDC domain
IPR002562 3\'-5\' exonuclease domain
IPR010997 HRDC-like
IPR012337 Ribonuclease H-like domain
IPR012588 Exosome-associated factor Rrp6, N-terminal

PFAM

PF00570
PF01612
PF08066

PRINTS

PIRSF

SMART

SM00341
SM00474

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite