InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: SNX27

Summary

InnateDB Protein

IDBP-684722.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SNX27

Protein Name

Sorting nexin-27

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000033754

InnateDB Gene

IDBG-633056 (SNX27)

Protein Structure

UniProt Annotation

Function

Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ- binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes (By similarity). {ECO:0000250}.

Subcellular Localization

Early endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Note=Localizes to immunological synapse in T-cells. In T-cells, recruited from the cytosol to sorting endosomes by phosphoinositide-3-kinase products (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008289	lipid binding
GO:0032266	phosphatidylinositol-3-phosphate binding
GO:0035091	phosphatidylinositol binding

Biological Process

GO:0006810	transport
GO:0006886	intracellular protein transport
GO:0007165	signal transduction
GO:0008333	endosome to lysosome transport
GO:0015031	protein transport
GO:0016197	endosomal transport
GO:1990126	retrograde transport, endosome to plasma membrane

Cellular Component

GO:0001772	immunological synapse
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005769	early endosome
GO:0005829	cytosol
GO:0016020	membrane
GO:0030904	retromer complex
GO:0031901	early endosome membrane
GO:0071203	WASH complex

Protein Structure and Domains

PDB ID

InterPro

IPR000159 Ras-association
IPR001478 PDZ domain
IPR001683 Phox homologous domain
IPR029071 Ubiquitin-related domain

PFAM

PF00788
PF00595
PF13180
PF00787

PRINTS

PIRSF

SMART

SM00314
SM00228
SM00312

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A5PKA5

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

513214

UniGene

Bt.39730

RefSeq

NP_001092426

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC142417

GenPept

AAI42418