Version 5.4
Bos taurus Protein: EPAS1
Summary
InnateDB Protein IDBP-685011.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EPAS1
Protein Name endothelial PAS domain-containing protein 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000004836
InnateDB Gene IDBG-633312 (EPAS1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 99 interaction(s) predicted by orthology.
Predicted by orthology
Total 99 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0035035 histone acetyltransferase binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
Biological Process
GO:0001525 angiogenesis
GO:0001666 response to hypoxia
GO:0001892 embryonic placenta development
GO:0001974 blood vessel remodeling
GO:0002027 regulation of heart rate
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006979 response to oxidative stress
GO:0007005 mitochondrion organization
GO:0007165 signal transduction
GO:0007601 visual perception
GO:0030097 hemopoiesis
GO:0030154 cell differentiation
GO:0030218 erythrocyte differentiation
GO:0030324 lung development
GO:0042415 norepinephrine metabolic process
GO:0043129 surfactant homeostasis
GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048469 cell maturation
GO:0048625 myoblast fate commitment
GO:0071456 cellular response to hypoxia
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000014 PAS domain
IPR001067 Nuclear translocator
IPR001610 PAC motif
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
IPR013655 PAS fold-3
IPR013767 PAS fold
IPR014887 HIF-1 alpha, transactivation domain, C-terminal
IPR021537 Hypoxia-inducible factor, alpha subunit
PFAM PF13188
PF13426
PF00010
PF08447
PF00989
PF08778
PF11413
PRINTS PR00785
PIRSF
SMART SM00091
SM00086
SM00353
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL A5PJT1
UniProt Splice Variant
Entrez Gene 282711
UniGene Bt.45570
RefSeq NP_777150
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC142229 DAAA02030718 DAAA02030719
GenPept AAI42230

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca