InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MAP1LC3A

Summary

InnateDB Protein

IDBP-68520.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAP1LC3A

Protein Name

microtubule-associated protein 1 light chain 3 alpha

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000353886

InnateDB Gene

IDBG-68516 (MAP1LC3A)

Protein Structure

UniProt Annotation

Function

Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. {ECO:0000269PubMed:20713600}.

Subcellular Localization

Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Note=LC3-II binds to the autophagic membranes.

Disease Associations

Tissue Specificity

Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes. {ECO:0000269PubMed:12740394}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 152 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	152 [view]
Protein-Protein	152 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0008429	phosphatidylethanolamine binding

Biological Process

GO:0000045	autophagic vacuole assembly
GO:0000422	mitochondrion degradation

Cellular Component

GO:0000421	autophagic vacuole membrane
GO:0005737	cytoplasm
GO:0005776	autophagic vacuole
GO:0005829	cytosol
GO:0005874	microtubule
GO:0031090	organelle membrane
GO:0031410	cytoplasmic vesicle