Version 5.4
Homo sapiens Gene: MAP1LC3A
Summary
InnateDB Gene IDBG-68516.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAP1LC3A
Gene Name microtubule-associated protein 1 light chain 3 alpha
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000101460
Encoded Proteins
IDBP-68518
microtubule-associated protein 1 light chain 3 alpha
IDBP-68520
microtubule-associated protein 1 light chain 3 alpha
IDBP-234764
microtubule-associated protein 1 light chain 3 alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B. Two transcript variants encoding different isoforms have been found for this gene. The expression of variant 1 is suppressed in many tumor cell lines, suggesting that may be involved in carcinogenesis. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:34546854-34560345
Strand Forward strand
Band q11.22
Transcripts
ENST00000374837 ENSP00000363970
ENST00000360668 ENSP00000353886
ENST00000397709 ENSP00000380821
ENST00000476428
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 152 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 152 [view]
Protein-Protein 152 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0008429 phosphatidylethanolamine binding
Biological Process
GO:0000045 autophagic vacuole assembly
GO:0000422 mitochondrion degradation
GO:0006914 autophagy
Cellular Component
GO:0000421 autophagic vacuole membrane
GO:0005737 cytoplasm
GO:0005770 late endosome
GO:0005776 autophagic vacuole
GO:0005829 cytosol
GO:0005874 microtubule
GO:0031090 organelle membrane
GO:0031410 cytoplasmic vesicle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027602
View Gene Order
ENSBTAG00000006135
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_032514 NM_181509
HUGO
OMIM
CCDS CCDS13237 CCDS13238
HPRD 03144
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca