InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: RDBP

Summary

InnateDB Protein

IDBP-685373.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RDBP

Protein Name

Negative elongation factor E

Synonyms

RDBP;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000009802

InnateDB Gene

IDBG-633652 (RDBP)

Protein Structure

UniProt Annotation

Function

Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0034244	negative regulation of transcription elongation from RNA polymerase II promoter

Cellular Component

GO:0005634	nucleus
GO:0032021	NELF complex

Protein Structure and Domains

PDB ID

InterPro

IPR000504 RNA recognition motif domain

PFAM

PF00076

PRINTS

PIRSF

SMART

SM00360

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q0V898

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

540158

UniGene

Bt.36000

RefSeq

NP_001069672

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC120072 BT026321

GenPept

AAI20073 ABG81477