Bos taurus Gene: RDBP
Summary
InnateDB Gene IDBG-633652.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RDBP
Gene Name Negative elongation factor E
Synonyms RDBP
Species Bos taurus
Ensembl Gene ENSBTAG00000007453
Encoded Proteins
Negative elongation factor E
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204356:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] The protein encoded by this gene is part of a complex termed negative elongation factor (NELF) which represses RNA polymerase II transcript elongation. This protein bears similarity to nuclear RNA-binding proteins; however, it has not been demonstrated that this protein binds RNA. The protein contains a tract of alternating basic and acidic residues, largely arginine (R) and aspartic acid (D). The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is part of a complex termed negative elongation factor (NELF) which represses RNA polymerase II transcript elongation. This protein bears similarity to nuclear RNA-binding proteins; however, it has not been demonstrated that this protein binds RNA. The protein contains a tract of alternating basic and acidic residues, largely arginine (R) and aspartic acid (D). The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 23:27219377-27225118
Strand Forward strand
Band
Transcripts
ENSBTAT00000009802 ENSBTAP00000009802
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0032021 NELF complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Pathways
NETPATH
REACTOME
RNA Polymerase II Transcription pathway
RNA Polymerase II Pre-transcription Events pathway
Gene Expression pathway
RNA Polymerase II Transcription Elongation pathway
Formation of RNA Pol II elongation complex pathway
Formation of the Early Elongation Complex pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Tat-mediated HIV elongation arrest and recovery pathway
Pausing and recovery of Tat-mediated HIV elongation pathway
RNA Polymerase II Pre-transcription Events pathway
Formation of RNA Pol II elongation complex pathway
Formation of the Early Elongation Complex pathway
RNA Polymerase II Transcription Elongation pathway
Formation of HIV elongation complex in the absence of HIV Tat pathway
Pausing and recovery of HIV elongation pathway
Formation of the HIV-1 Early Elongation Complex pathway
Formation of HIV-1 elongation complex containing HIV-1 Tat pathway
Tat-mediated elongation of the HIV-1 transcript pathway
Abortive elongation of HIV-1 transcript in the absence of Tat pathway
HIV elongation arrest and recovery pathway
Transcription of the HIV genome pathway
Late Phase of HIV Life Cycle pathway
HIV Transcription Elongation pathway
RNA Polymerase II Transcription pathway
HIV Life Cycle pathway
HIV Infection pathway
Gene Expression pathway
Disease pathway
Formation of the Early Elongation Complex pathway
Formation of RNA Pol II elongation complex pathway
RNA Polymerase II Transcription Elongation pathway
RNA Polymerase II Pre-transcription Events pathway
Gene Expression pathway
RNA Polymerase II Transcription pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q0V898
TrEMBL
UniProt Splice Variant
Entrez Gene 540158
UniGene Bt.36000
RefSeq NM_001076204
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC120072 BT026321
GenPept AAI20073 ABG81477
RNA Seq Atlas 540158