InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NRP1

Summary

InnateDB Protein

IDBP-68538.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NRP1

Protein Name

neuropilin 1

Synonyms

BDCA4; CD304; NP1; NRP; VEGF165R;

Species

Homo sapiens

Ensembl Protein

ENSP00000364001

InnateDB Gene

IDBG-68532 (NRP1)

Protein Structure

UniProt Annotation

Function

The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis.The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein.Isoform 2: Secreted.

Disease Associations

Tissue Specificity

The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	29 [view]
Protein-Protein	29 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005021	vascular endothelial growth factor-activated receptor activity
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0015026	coreceptor activity
GO:0017154	semaphorin receptor activity
GO:0019838	growth factor binding
GO:0019955	cytokine binding
GO:0038085	vascular endothelial growth factor binding
GO:0046872	metal ion binding

Biological Process

GO:0001525	angiogenesis
GO:0001569	patterning of blood vessels
GO:0001764	neuron migration
GO:0001938	positive regulation of endothelial cell proliferation
GO:0002040	sprouting angiogenesis
GO:0002042	cell migration involved in sprouting angiogenesis
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0007411	axon guidance
GO:0009887	organ morphogenesis
GO:0010595	positive regulation of endothelial cell migration
GO:0014911	positive regulation of smooth muscle cell migration
GO:0021675	nerve development
GO:0031290	retinal ganglion cell axon guidance
GO:0035729	cellular response to hepatocyte growth factor stimulus
GO:0035767	endothelial cell chemotaxis
GO:0035924	cellular response to vascular endothelial growth factor stimulus
GO:0038084	vascular endothelial growth factor signaling pathway
GO:0038190	VEGF-activated neuropilin signaling pathway
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0048012	hepatocyte growth factor receptor signaling pathway
GO:0048842	positive regulation of axon extension involved in axon guidance
GO:0048844	artery morphogenesis
GO:0048846	axon extension involved in axon guidance
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050918	positive chemotaxis
GO:0060301	positive regulation of cytokine activity
GO:0060385	axonogenesis involved in innervation
GO:0060627	regulation of vesicle-mediated transport
GO:0060978	angiogenesis involved in coronary vascular morphogenesis
GO:0061299	retina vasculature morphogenesis in camera-type eye
GO:0061549	sympathetic ganglion development
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0071526	semaphorin-plexin signaling pathway
GO:0071679	commissural neuron axon guidance
GO:0090259	regulation of retinal ganglion cell axon guidance
GO:0097102	endothelial tip cell fate specification
GO:0097490	sympathetic neuron projection extension
GO:0097491	sympathetic neuron projection guidance
GO:1901166	neural crest cell migration involved in autonomic nervous system development
GO:1902285	semaphorin-plexin signaling pathway involved in neuron projection guidance
GO:1902336	positive regulation of retinal ganglion cell axon guidance
GO:1902946	protein localization to early endosome

Cellular Component

GO:0002116	semaphorin receptor complex
GO:0005615	extracellular space
GO:0005769	early endosome
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0031410	cytoplasmic vesicle
GO:0043235	receptor complex
GO:0097443	sorting endosome

Protein Structure and Domains

PDB ID

InterPro

IPR000421 Coagulation factor 5/8 C-terminal type domain
IPR000859 CUB domain
IPR000998 MAM domain
IPR008979 Galactose-binding domain-like
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR014648 Neuropilin
IPR022579 Neuropilin-1, C-terminal

PFAM

PF00754
PF00431
PF00629
PF11980

PRINTS

PR00020

PIRSF

PIRSF036960

SMART

SM00231
SM00042
SM00137

TIGRFAMs

Post-translational Modifications

Modification

Cross-References