InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: TNFAIP3

Summary

InnateDB Protein

IDBP-685422.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNFAIP3

Protein Name

tumor necrosis factor, alpha-induced protein 3

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000000557

InnateDB Gene

IDBG-633691 (TNFAIP3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 72 interaction(s) predicted by orthology.

Predicted by orthology
Total	72 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0003677	DNA binding
GO:0004221	ubiquitin thiolesterase activity
GO:0004842	ubiquitin-protein transferase activity
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019900	kinase binding
GO:0043130	ubiquitin binding
GO:0043621	protein self-association

Biological Process

GO:0001922	B-1 B cell homeostasis
GO:0002237	response to molecule of bacterial origin
GO:0002634	regulation of germinal center formation
GO:0002677	negative regulation of chronic inflammatory response
GO:0016579	protein deubiquitination
GO:0031397	negative regulation of protein ubiquitination
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032495	response to muramyl dipeptide
GO:0032691	negative regulation of interleukin-1 beta production
GO:0032703	negative regulation of interleukin-2 production
GO:0032715	negative regulation of interleukin-6 production
GO:0032720	negative regulation of tumor necrosis factor production
GO:0034140	negative regulation of toll-like receptor 3 signaling pathway
GO:0034148	negative regulation of toll-like receptor 5 signaling pathway
GO:0035871	protein K11-linked deubiquitination
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045732	positive regulation of protein catabolic process
GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045824	negative regulation of innate immune response
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0050728	negative regulation of inflammatory response
GO:0050869	negative regulation of B cell activation
GO:0060548	negative regulation of cell death
GO:0070301	cellular response to hydrogen peroxide
GO:0070429	negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070433	negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0070536	protein K63-linked deubiquitination
GO:0070936	protein K48-linked ubiquitination
GO:0071108	protein K48-linked deubiquitination
GO:0071222	cellular response to lipopolysaccharide
GO:0072573	tolerance induction to lipopolysaccharide
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000347	positive regulation of hepatocyte proliferation
GO:2000349	negative regulation of CD40 signaling pathway
GO:2000352	negative regulation of endothelial cell apoptotic process