InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NRP1

Summary

InnateDB Protein

IDBP-68548.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NRP1

Protein Name

neuropilin 1

Synonyms

BDCA4; CD304; NP1; NRP; VEGF165R;

Species

Homo sapiens

Ensembl Protein

ENSP00000363954

InnateDB Gene

IDBG-68532 (NRP1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	29 [view]
Protein-Protein	29 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005021	vascular endothelial growth factor-activated receptor activity
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0015026	coreceptor activity
GO:0017154	semaphorin receptor activity
GO:0019838	growth factor binding
GO:0019955	cytokine binding
GO:0038085	vascular endothelial growth factor binding
GO:0046872	metal ion binding

Biological Process

GO:0001525	angiogenesis
GO:0001569	patterning of blood vessels
GO:0001764	neuron migration
GO:0001938	positive regulation of endothelial cell proliferation
GO:0002040	sprouting angiogenesis
GO:0002042	cell migration involved in sprouting angiogenesis
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0007411	axon guidance
GO:0009887	organ morphogenesis
GO:0010595	positive regulation of endothelial cell migration
GO:0014911	positive regulation of smooth muscle cell migration
GO:0021675	nerve development
GO:0031290	retinal ganglion cell axon guidance
GO:0035729	cellular response to hepatocyte growth factor stimulus
GO:0035767	endothelial cell chemotaxis
GO:0035924	cellular response to vascular endothelial growth factor stimulus
GO:0038084	vascular endothelial growth factor signaling pathway
GO:0038190	VEGF-activated neuropilin signaling pathway
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0048012	hepatocyte growth factor receptor signaling pathway
GO:0048842	positive regulation of axon extension involved in axon guidance
GO:0048844	artery morphogenesis
GO:0048846	axon extension involved in axon guidance
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050918	positive chemotaxis
GO:0060301	positive regulation of cytokine activity
GO:0060385	axonogenesis involved in innervation
GO:0060627	regulation of vesicle-mediated transport
GO:0060978	angiogenesis involved in coronary vascular morphogenesis
GO:0061299	retina vasculature morphogenesis in camera-type eye
GO:0061549	sympathetic ganglion development
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0071526	semaphorin-plexin signaling pathway
GO:0071679	commissural neuron axon guidance
GO:0090259	regulation of retinal ganglion cell axon guidance
GO:0097102	endothelial tip cell fate specification
GO:0097490	sympathetic neuron projection extension
GO:0097491	sympathetic neuron projection guidance
GO:1901166	neural crest cell migration involved in autonomic nervous system development
GO:1902285	semaphorin-plexin signaling pathway involved in neuron projection guidance
GO:1902336	positive regulation of retinal ganglion cell axon guidance
GO:1902946	protein localization to early endosome

Cellular Component

GO:0002116	semaphorin receptor complex
GO:0005615	extracellular space
GO:0005769	early endosome
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0031410	cytoplasmic vesicle
GO:0043235	receptor complex
GO:0097443	sorting endosome