InnateDB Protein
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IDBP-685508.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CHGA
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Protein Name
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chromogranin-A
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Synonyms
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000012973
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InnateDB Gene
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IDBG-633773 (CHGA)
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Protein Structure
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Function |
Pancreastatin strongly inhibits glucose induced insulin release from the pancreas.Chromostatin completely inhibits catecholamine release from chromaffin cells.Chromacin has antibacterial activity against M.luteus. Not active against E.coli.Catestatin inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non- competitive nicotinic cholinergic antagonist.Vasostatin-1 has antibacterial activity against Gram- positive bacteria M.luteus, B.megaterium. Not active against Gram- positive bacteria B.cereus, B.subtilis, S.pyogenes, M.fortuitum, S.aureus and L.monocytogenes and against Gram-negative bacteria E.coli, E.cloacae, S.typhimurium, K.pneumoniae and P.aeruginosa. Possesses antifungal activity against N.crassa, A.fumigatus, A.brassicicola, N.hematococca, F.culmorum and F.oxyporum and against the yeast S.cerevisiae and C.albicans. Inactive against T.mentagrophytes.
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Subcellular Localization |
Cytoplasmic vesicle, secretory vesicle lumen {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}. Secreted. Note=Associated with the secretory granule membrane through direct interaction to SCG3 that in turn binds to cholesterol-enriched lipid rafts in intragranular conditions. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001819
Chromogranin A/B
IPR001990
Chromogranin/secretogranin
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PFAM |
PF01271
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PRINTS |
PR00659
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P05059
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PhosphoSite |
PhosphoSite-P05059
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
281070
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UniGene |
Bt.49630
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RefSeq |
NP_851348
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
BC105515
M16971
S79256
S79258
S79260
S79262
S79264
S79266
S79268
S79270
U73523
X04012
X04298
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GenPept |
AAA30765
AAB21297
AAC48700
AAI05516
CAA27636
CAA27841
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