Version 5.4
Bos taurus Gene: CHGA
Summary
InnateDB Gene IDBG-633773.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHGA
Gene Name Chromogranin-A Vasostatin-1 Chromostatin Chromacin Pancreastatin WE-14 Catestatin
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000009836
Encoded Proteins
IDBP-685508
chromogranin-A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 21214543
[Homo sapiens] CHGA undergoes proteolytic cleavage to give rise to biologically active peptides, including catestatin. Catestatin is a neuroendocrine peptide with effects on human autonomic function and has recently been found to be a cutaneous antimicrobial peptide by inducing mast cell activation. In mast cells, catestatin plays a role in the migration, degranulation and release of leukotriene and prostaglandins; in addition, catestatin also induces production of pro-inflammatory cytokines to prime the innate immune response.
PMID 21214543
[Mus musculus] Chga undergoes proteolytic cleavage to give rise to biologically active peptides, including catestatin. Catestatin is a neuroendocrine peptide with effects on human autonomic function and has recently been found to be a cutaneous antimicrobial peptide by inducing mast cell activation. In mast cells, catestatin plays a role in the migration, degranulation and release of leukotriene and prostaglandins; in addition, catestatin also induces production of pro-inflammatory cytokines to prime the innate immune response.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100604:
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. However, biological activities for these molecules have not been shown. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Two other peptides, catestatin and chromofungin, have antimicrobial activity and antifungal activity, respectively. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:58163028-58176319
Strand Forward strand
Band
Transcripts
ENSBTAT00000012973 ENSBTAP00000012973
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0016525 negative regulation of angiogenesis
GO:0030155 regulation of cell adhesion
GO:0031640 killing of cells of other organism
GO:0042742 defense response to bacterium
GO:0045087 innate immune response
GO:0046676 negative regulation of insulin secretion
GO:0046888 negative regulation of hormone secretion
GO:0050829 defense response to Gram-negative bacterium
GO:0050830 defense response to Gram-positive bacterium
GO:0050832 defense response to fungus
Cellular Component
GO:0005576 extracellular region
GO:0016020 membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0030141 secretory granule
GO:0030658 transport vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000100604
View Gene Order
ENSMUSG00000021194
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.49630
RefSeq NM_181005
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca