Version 5.4
Bos taurus Protein: PLP1
Summary
InnateDB Protein IDBP-685688.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLP1
Protein Name Myelin proteolipid protein
Synonyms PLP;
Species Bos taurus
Ensembl Protein ENSBTAP00000009171
InnateDB Gene IDBG-633948 (PLP1)
Protein Structure
UniProt Annotation
Function This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.
Subcellular Localization Cell membrane; Multi-pass membrane protein. Myelin membrane {ECO:0000250}. Note=Colocalizes with SIRT2 in internodal regions, at paranodal axoglial junction and Schmidt- Lanterman incisures of myelin sheat. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006954 inflammatory response
GO:0008366 axon ensheathment
GO:0010628 positive regulation of gene expression
GO:0014002 astrocyte development
GO:0021762 substantia nigra development
GO:0022010 central nervous system myelination
GO:0042552 myelination
GO:0042759 long-chain fatty acid biosynthetic process
GO:0048469 cell maturation
GO:0061564 axon development
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043209 myelin sheath
Protein Structure and Domains
PDB ID
InterPro IPR001614 Myelin proteolipid protein PLP
PFAM PF01275
PRINTS PR00214
PIRSF
SMART SM00002
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P04116
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281410
UniGene Bt.72085
RefSeq NP_776574
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AJ009913 BC103102 BC133388 X03098
GenPept AAI03103 AAI33389 CAA08909 CAA26884

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca