Version 5.4
Bos taurus Gene: PLP1
Summary
InnateDB Gene IDBG-633948.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLP1
Gene Name Myelin proteolipid protein
Synonyms PLP
Species Bos taurus
Ensembl Gene ENSBTAG00000006977
Encoded Proteins
IDBP-685688
Myelin proteolipid protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000123560:
This gene encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively spliced transcript variants encoding distinct isoforms or having different 5' UTRs, have been identified for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively spliced transcript variants encoding distinct isoforms or having different 5\' UTRs, have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:57865111-57880915
Strand Forward strand
Band
Transcripts
ENSBTAT00000009171 ENSBTAP00000009171
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006954 inflammatory response
GO:0008366 axon ensheathment
GO:0010628 positive regulation of gene expression
GO:0014002 astrocyte development
GO:0021762 substantia nigra development
GO:0022010 central nervous system myelination
GO:0042552 myelination
GO:0042759 long-chain fatty acid biosynthetic process
GO:0048469 cell maturation
GO:0061564 axon development
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043209 myelin sheath
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000123560
View Gene Order
ENSMUSG00000031425
View Gene Order
Cross-References
SwissProt P04116
TrEMBL
UniProt Splice Variant
Entrez Gene 281410
UniGene Bt.106918 Bt.72085
RefSeq NM_174149
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AJ009913 BC103102 BC133388 X03098
GenPept AAI03103 AAI33389 CAA08909 CAA26884
RNA Seq Atlas 281410

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca