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InnateDB Protein
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IDBP-685722.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DDAH2
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Protein Name
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N(G),N(G)-dimethylarginine dimethylaminohydrolase 2
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Synonyms
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000017991
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InnateDB Gene
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IDBG-633979 (DDAH2)
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Protein Structure
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| Function |
Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation (By similarity). {ECO:0000250}.
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| Subcellular Localization |
Cytoplasm {ECO:0000250}. Mitochondrion {ECO:0000250}. Note=Translocates from cytosol to mitochondrion upon IL-1beta stimulation in chondrocytes. {ECO:0000250}.
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| Disease Associations |
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| Tissue Specificity |
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
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| Predicted by orthology |
| Total |
20 [view]
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Molecular Function |
| Accession |
GO Term |
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GO:0005515
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protein binding
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GO:0016403
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dimethylargininase activity
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GO:0016787
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hydrolase activity
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GO:0016813
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hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
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| Biological Process |
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GO:0000052
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citrulline metabolic process
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GO:0045429
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positive regulation of nitric oxide biosynthetic process
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| Cellular Component |
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| PDB ID |
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| InterPro |
IPR003198
Amidinotransferase
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| PFAM |
PF02274
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
Q3SX44
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| PhosphoSite |
PhosphoSite-
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
540386
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| UniGene |
Bt.57614
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| RefSeq |
NP_001029876
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| HUGO |
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| OMIM |
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| CCDS |
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| HPRD |
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| IMGT |
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| EMBL |
BC104509
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| GenPept |
AAI04510
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Version 5.4