Version 5.4
Bos taurus Gene: DDAH2
Summary
InnateDB Gene IDBG-633979.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DDAH2
Gene Name N(G),N(G)-dimethylarginine dimethylaminohydrolase 2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000013530
Encoded Proteins
IDBP-685722
N(G),N(G)-dimethylarginine dimethylaminohydrolase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000213722:
This gene belongs to the dimethylarginine dimethylaminohydrolase (DDAH) gene family. The encoded enzyme plays a role in nitric oxide generation by regulating cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 23:27399306-27402825
Strand Forward strand
Band
Transcripts
ENSBTAT00000017991 ENSBTAP00000017991
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016403 dimethylargininase activity
GO:0016787 hydrolase activity
GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
Biological Process
GO:0000052 citrulline metabolic process
GO:0045429 positive regulation of nitric oxide biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Homo sapiens
Gene ID
Gene Order
ENSMUSG00000007039
View Gene Order
ENSG00000213722
View Gene Order
Cross-References
SwissProt Q3SX44
TrEMBL
UniProt Splice Variant
Entrez Gene 540386
UniGene Bt.57614
RefSeq NM_001034704
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC104509
GenPept AAI04510
RNA Seq Atlas 540386

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca