InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: MDM2

Summary

InnateDB Protein

IDBP-685825.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MDM2

Protein Name

E3 ubiquitin-protein ligase Mdm2

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000042668

InnateDB Gene

IDBG-634069 (MDM2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 332 interaction(s) predicted by orthology.

Predicted by orthology
Total	332 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019899	enzyme binding
GO:0031625	ubiquitin protein ligase binding
GO:0042802	identical protein binding
GO:0046872	metal ion binding
GO:0097110	scaffold protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006461	protein complex assembly
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007089	traversing start control point of mitotic cell cycle
GO:0016567	protein ubiquitination
GO:0018205	peptidyl-lysine modification
GO:0030163	protein catabolic process
GO:0031648	protein destabilization
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034504	protein localization to nucleus
GO:0042176	regulation of protein catabolic process
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043066	negative regulation of apoptotic process
GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045184	establishment of protein localization
GO:0045787	positive regulation of cell cycle
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045931	positive regulation of mitotic cell cycle
GO:0046677	response to antibiotic
GO:0071157	negative regulation of cell cycle arrest
GO:0071456	cellular response to hypoxia