Version 5.4
Bos taurus Gene: MDM2
Summary
InnateDB Gene IDBG-634069.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MDM2
Gene Name Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000010422
Encoded Proteins
IDBP-685825
E3 ubiquitin-protein ligase Mdm2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135679:
This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues. [provided by RefSeq, Jul 2008]
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:45178135-45203567
Strand Reverse strand
Band
Transcripts
ENSBTAT00000045265 ENSBTAP00000042668
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 332 interaction(s) predicted by orthology.
Predicted by orthology
Total 332 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002039 p53 binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0019899 enzyme binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0097110 scaffold protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006461 protein complex assembly
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007089 traversing start control point of mitotic cell cycle
GO:0016567 protein ubiquitination
GO:0018205 peptidyl-lysine modification
GO:0030163 protein catabolic process
GO:0031648 protein destabilization
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034504 protein localization to nucleus
GO:0042176 regulation of protein catabolic process
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043066 negative regulation of apoptotic process
GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045184 establishment of protein localization
GO:0045787 positive regulation of cell cycle
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045931 positive regulation of mitotic cell cycle
GO:0046677 response to antibiotic
GO:0071157 negative regulation of cell cycle arrest
GO:0071456 cellular response to hypoxia
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0016604 nuclear body
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000135679
View Gene Order
ENSMUSG00000020184
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_2
AndrogenReceptor pathway
NetPath_25
FSH pathway
REACTOME
REACT_309
Stabilization of p53 pathway
REACT_1625
p53-Dependent G1 DNA Damage Response pathway
REACT_12564
AKT phosphorylates targets in the cytosol pathway
REACT_75829
PIP3 activates AKT signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_12464
PI3K/AKT activation pathway
REACT_12578
GAB1 signalosome pathway
REACT_9417
Signaling by EGFR pathway
REACT_115961
PI3K events in ERBB4 signaling pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_116008
PI3K events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_21270
PI-3K cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_147727
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_18307
Trafficking of AMPA receptors pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_85
p53-Dependent G1/S DNA damage checkpoint pathway
REACT_120956
Cellular responses to stress pathway
REACT_169325
Oncogene Induced Senescence pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_13685
Neuronal System pathway
REACT_163769
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_6802
Innate Immune System pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_115566
Cell Cycle pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_169274
Cellular Senescence pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_147723
PI3K/AKT Signaling in Cancer pathway
REACT_2254
G1/S DNA Damage Checkpoints pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_18347
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity pathway
REACT_169436
Oxidative Stress Induced Senescence pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_116125
Disease pathway
REACT_1538
Cell Cycle Checkpoints pathway
REACT_239142
Innate Immune System pathway
REACT_188970
Oxidative Stress Induced Senescence pathway
REACT_188199
Signaling by the B Cell Receptor (BCR) pathway
REACT_188191
Signaling by ERBB2 pathway
REACT_205300
PI3K/AKT activation pathway
REACT_189085
Disease pathway
REACT_188957
Cellular responses to stress pathway
REACT_188177
Signaling by FGFR in disease pathway
REACT_188579
Signaling by ERBB4 pathway
REACT_188578
Signaling by SCF-KIT pathway
REACT_188971
Oncogene Induced Senescence pathway
REACT_257943
p53-Dependent G1 DNA Damage Response pathway
REACT_254524
p53-Dependent G1/S DNA damage checkpoint pathway
REACT_226341
PIP3 activates AKT signaling pathway
REACT_188804
Cell Cycle pathway
REACT_256790
Stabilization of p53 pathway
REACT_230745
Immune System pathway
REACT_256025
Cell Cycle Checkpoints pathway
REACT_230639
Downstream signal transduction pathway
REACT_231729
Downstream signaling of activated FGFR pathway
REACT_196588
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_203296
PI3K events in ERBB4 signaling pathway
REACT_223993
PI-3K cascade pathway
REACT_188820
Cellular Senescence pathway
REACT_242976
Signaling by EGFR pathway
REACT_246312
G1/S DNA Damage Checkpoints pathway
REACT_213364
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_188204
Fc epsilon receptor (FCERI) signaling pathway
REACT_226735
PI3K/AKT Signaling in Cancer pathway
REACT_248921
Signalling by NGF pathway
REACT_229531
Adaptive Immune System pathway
REACT_263353
Signaling by PDGF pathway
REACT_206286
GAB1 signalosome pathway
REACT_220918
AKT phosphorylates targets in the cytosol pathway
REACT_237883
NGF signalling via TRKA from the plasma membrane pathway
REACT_215348
PI3K events in ERBB2 signaling pathway
REACT_188257
Signal Transduction pathway
REACT_242456
Signaling by FGFR pathway
REACT_188180
Signaling by EGFR in Cancer pathway
REACT_209507
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_188188
DAP12 interactions pathway
REACT_188185
DAP12 signaling pathway
KEGG
hsa04110
Cell cycle pathway
hsa05218
Melanoma pathway
hsa05219
Bladder cancer pathway
hsa04120
Ubiquitin mediated proteolysis pathway
hsa05214
Glioma pathway
hsa05215
Prostate cancer pathway
hsa05220
Chronic myeloid leukemia pathway
hsa04115
p53 signaling pathway pathway
hsa04144
Endocytosis pathway
hsa05200
Pathways in cancer pathway
mmu05219
Bladder cancer pathway
mmu04120
Ubiquitin mediated proteolysis pathway
mmu04115
p53 signaling pathway pathway
mmu05218
Melanoma pathway
mmu04110
Cell cycle pathway
mmu05214
Glioma pathway
mmu05215
Prostate cancer pathway
mmu05220
Chronic myeloid leukemia pathway
mmu04144
Endocytosis pathway
mmu05200
Pathways in cancer pathway
INOH
INOH website
Tryptophan degradation pathway
PID NCI
rb_1pathway
Regulation of retinoblastoma protein
aurora_a_pathway
Aurora A signaling
erbb4_pathway
ErbB4 signaling events
p53downstreampathway
Direct p53 effectors
p53regulationpathway
p53 pathway
reg_gr_pathway
Glucocorticoid receptor regulatory network
p73pathway
p73 transcription factor network
ranbp2pathway
Sumoylation by RanBP2 regulates transcriptional repression
atm_pathway
ATM pathway
atr_pathway
ATR signaling pathway
ar_tf_pathway
Regulation of Androgen receptor activity
deltanp63pathway
Validated transcriptional targets of deltaNp63 isoforms
tap63pathway
Validated transcriptional targets of TAp63 isoforms
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.110998 Bt.65406
RefSeq NM_001099107 XM_005206462
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca