InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PIGU

Summary

InnateDB Protein

IDBP-68587.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PIGU

Protein Name

phosphatidylinositol glycan anchor biosynthesis, class U

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000363953

InnateDB Gene

IDBG-68583 (PIGU)

Protein Structure

UniProt Annotation

Function

Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI. {ECO:0000269PubMed:12802054}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003923	GPI-anchor transamidase activity
GO:0034235	GPI anchor binding

Biological Process

GO:0006501	C-terminal protein lipidation
GO:0006506	GPI anchor biosynthetic process
GO:0016255	attachment of GPI anchor to protein
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0046425	regulation of JAK-STAT cascade

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030176	integral component of endoplasmic reticulum membrane
GO:0042765	GPI-anchor transamidase complex