Version 5.4
Bos taurus Protein: AIF1
Summary
InnateDB Protein IDBP-685898.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AIF1
Protein Name Allograft inflammatory factor 1
Synonyms AIF;
Species Bos taurus
Ensembl Protein ENSBTAP00000027388
InnateDB Gene IDBG-634144 (AIF1)
Protein Structure
UniProt Annotation
Function May play a role in macrophage activation and function. {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0046872 metal ion binding
GO:0051015 actin filament binding
Biological Process
GO:0006911 phagocytosis, engulfment
GO:0006954 inflammatory response
GO:0016601 Rac protein signal transduction
GO:0030041 actin filament polymerization
GO:0042102 positive regulation of T cell proliferation
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0051017 actin filament bundle assembly
GO:0071346 cellular response to interferon-gamma
GO:0071672 negative regulation of smooth muscle cell chemotaxis
GO:0071673 positive regulation of smooth muscle cell chemotaxis
GO:0090026 positive regulation of monocyte chemotaxis
GO:0097178 ruffle assembly
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:2000406 positive regulation of T cell migration
Cellular Component
GO:0001726 ruffle
GO:0001891 phagocytic cup
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005884 actin filament
GO:0030027 lamellipodium
GO:0032587 ruffle membrane
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR002048 EF-hand domain
PFAM PF00036
PF13202
PF13405
PRINTS
PIRSF
SMART SM00054
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BDK2
PhosphoSite PhosphoSite-
TrEMBL Q3KUS5
UniProt Splice Variant
Entrez Gene 280989
UniGene
RefSeq NP_776410
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF348450 AY881697 BC102890
GenPept AAI02891 AAK30155 AAY57797

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca