Version 5.4
Bos taurus Gene: AIF1
Summary
InnateDB Gene IDBG-634144.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AIF1
Gene Name Allograft inflammatory factor 1
Synonyms AIF
Species Bos taurus
Ensembl Gene ENSBTAG00000020554
Encoded Proteins
IDBP-685898
Allograft inflammatory factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204472:
This gene is induced by cytokines and interferon. Its protein product is thought to be involved in negative regulation of growth of vascular smooth muscle cells, which contributes to the anti-inflammatory response to vessel wall trauma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 23:27503183-27505457
Strand Reverse strand
Band
Transcripts
ENSBTAT00000027388 ENSBTAP00000027388
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0046872 metal ion binding
GO:0051015 actin filament binding
Biological Process
GO:0006911 phagocytosis, engulfment
GO:0006954 inflammatory response
GO:0016601 Rac protein signal transduction
GO:0030041 actin filament polymerization
GO:0042102 positive regulation of T cell proliferation
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0051017 actin filament bundle assembly
GO:0071346 cellular response to interferon-gamma
GO:0071672 negative regulation of smooth muscle cell chemotaxis
GO:0071673 positive regulation of smooth muscle cell chemotaxis
GO:0090026 positive regulation of monocyte chemotaxis
GO:0097178 ruffle assembly
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:2000406 positive regulation of T cell migration
Cellular Component
GO:0001726 ruffle
GO:0001891 phagocytic cup
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005884 actin filament
GO:0030027 lamellipodium
GO:0032587 ruffle membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000204472
View Gene Order
ENSMUSG00000024397
View Gene Order
Cross-References
SwissProt Q9BDK2
TrEMBL Q3KUS5
UniProt Splice Variant
Entrez Gene 280989
UniGene
RefSeq NM_173985
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF348450 AY881697 BC102890
GenPept AAI02891 AAK30155 AAY57797
RNA Seq Atlas 280989

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca