Version 5.4
Bos taurus Protein: LTA
Summary
InnateDB Protein IDBP-685930.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LTA
Protein Name Lymphotoxin-alpha
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000000018
InnateDB Gene IDBG-634171 (LTA)
Protein Structure
UniProt Annotation
Function Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.
Subcellular Localization Secreted {ECO:0000250}. Membrane {ECO:0000250}. Note=The homotrimer is secreted. The heterotrimer is membrane-associated. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005515 protein binding
Biological Process
GO:0002876 positive regulation of chronic inflammatory response to antigenic stimulus
GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0006955 immune response
GO:0006959 humoral immune response
GO:0032729 positive regulation of interferon-gamma production
GO:0044130 negative regulation of growth of symbiont in host
GO:0048535 lymph node development
GO:0050830 defense response to Gram-positive bacterium
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR002960 Lymphotoxin-alpha
IPR006052 Tumour necrosis factor domain
IPR006053 Tumour necrosis factor
IPR008983 Tumour necrosis factor-like domain
PFAM PF00229
PRINTS PR01236
PR01234
PIRSF
SMART SM00207
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q06600
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 280845
UniGene Bt.37345
RefSeq NP_001013419
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC114670 Z14137
GenPept AAI14671 CAA78510

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca