InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: LTA

Summary

InnateDB Gene

IDBG-634171.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LTA

Gene Name

Lymphotoxin-alpha

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000016

Encoded Proteins

IDBP-685930

Lymphotoxin-alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000226979:
The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]
The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin\'s lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 23:27537907-27539470

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000000018

ENSBTAP00000000018

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding

Biological Process

GO:0002876	positive regulation of chronic inflammatory response to antigenic stimulus
GO:0002925	positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0006955	immune response
GO:0006959	humoral immune response
GO:0032729	positive regulation of interferon-gamma production
GO:0044130	negative regulation of growth of symbiont in host
GO:0048535	lymph node development
GO:0050830	defense response to Gram-positive bacterium