Version 5.4
Bos taurus Protein: F7
Summary
InnateDB Protein IDBP-686080.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol F7
Protein Name Coagulation factor VIIFactor VII light chainFactor VII heavy chain
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000009746
InnateDB Gene IDBG-634312 (F7)
Protein Structure
UniProt Annotation
Function Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Plasma.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001948 glycoprotein binding
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
GO:0016787 hydrolase activity
Biological Process
GO:0002690 positive regulation of leukocyte chemotaxis
GO:0006508 proteolysis
GO:0007596 blood coagulation
GO:0007599 hemostasis
GO:0010641 positive regulation of platelet-derived growth factor receptor signaling pathway
GO:0050927 positive regulation of positive chemotaxis
GO:0051897 positive regulation of protein kinase B signaling
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
IPR000742 Epidermal growth factor-like domain
IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR001881 EGF-like calcium-binding domain
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR012224 Peptidase S1A, coagulation factor VII/IX/X/C/Z
IPR015420 Peptidase S1A, nudel
PFAM PF00594
PF00008
PF00089
PF07645
PF09342
PRINTS PR00001
PR00722
PIRSF PIRSF001143
SMART SM00069
SM00181
SM00020
SM00179
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P22457
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 617960
UniGene Bt.37397
RefSeq NP_001029978
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC146045 BT021584
GenPept AAI46046 AAX46431

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca