InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: LATS1

Summary

InnateDB Protein

IDBP-686184.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LATS1

Protein Name

LATS, large tumor suppressor, homolog 1 (Drosophila)

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000020062

InnateDB Gene

IDBG-634406 (LATS1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.

Predicted by orthology
Total	42 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019901	protein kinase binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000819	sister chromatid segregation
GO:0006468	protein phosphorylation
GO:0007067	mitotic nuclear division
GO:0009755	hormone-mediated signaling pathway
GO:0016310	phosphorylation
GO:0030216	keratinocyte differentiation
GO:0030833	regulation of actin filament polymerization
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0034613	cellular protein localization
GO:0035329	hippo signaling
GO:0043254	regulation of protein complex assembly
GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0051220	cytoplasmic sequestering of protein
GO:0090090	negative regulation of canonical Wnt signaling pathway

Cellular Component

GO:0000922

spindle pole

Protein Structure and Domains

PDB ID

InterPro

IPR000449 Ubiquitin-associated domain/translation elongation factor EF-Ts, N-terminal
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR009060 UBA-like
IPR011009 Protein kinase-like domain
IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
IPR017892 Protein kinase, C-terminal
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00627
PF00069
PF07714
PF00433

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00165
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt