InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: LATS1

Summary

InnateDB Gene

IDBG-634406.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LATS1

Gene Name

serine/threonine-protein kinase LATS1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000015076

Encoded Proteins

IDBP-686184

LATS, large tumor suppressor, homolog 1 (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131023:
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. Two protein-coding transcripts and one non-protein coding transcript have been found for this gene. [provided by RefSeq, Jul 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:88008820-88046821

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000020062

ENSBTAP00000020062

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.

Predicted by orthology
Total	42 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019901	protein kinase binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000819	sister chromatid segregation
GO:0006468	protein phosphorylation
GO:0007067	mitotic nuclear division
GO:0009755	hormone-mediated signaling pathway
GO:0016310	phosphorylation
GO:0030216	keratinocyte differentiation
GO:0030833	regulation of actin filament polymerization
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0034613	cellular protein localization
GO:0035329	hippo signaling
GO:0043254	regulation of protein complex assembly
GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0051220	cytoplasmic sequestering of protein
GO:0090090	negative regulation of canonical Wnt signaling pathway

Cellular Component

GO:0000922

spindle pole

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000131023

View Gene Order

ENSMUSG00000040021

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_118607

Signaling by Hippo pathway

REACT_111102

Signal Transduction pathway

REACT_196537

Signaling by Hippo pathway

REACT_188257

Signal Transduction pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

E1BCH5

UniProt Splice Variant

Entrez Gene

535935

UniGene

Bt.111590 Bt.65003

RefSeq

NM_001192866

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02027051 DAAA02027052 DAAA02027053

GenPept

RNA Seq Atlas

535935