InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ATP6V1B2

Summary

InnateDB Protein

IDBP-686215.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP6V1B2

Protein Name

V-type proton ATPase subunit B, brain isoform

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000024812

InnateDB Gene

IDBG-634398 (ATP6V1B2)

Protein Structure

UniProt Annotation

Function

Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Subcellular Localization

Endomembrane system; Peripheral membrane protein. Melanosome {ECO:0000250}. Note=Endomembrane.

Disease Associations

Tissue Specificity

In all tissues tested, but highest in brain and in adrenal medulla.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.

Predicted by orthology
Total	45 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0015991	ATP hydrolysis coupled proton transport
GO:0015992	proton transport
GO:0046034	ATP metabolic process

Cellular Component

GO:0001726	ruffle
GO:0005737	cytoplasm
GO:0005765	lysosomal membrane
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005902	microvillus
GO:0012505	endomembrane system
GO:0016020	membrane
GO:0033178	proton-transporting two-sector ATPase complex, catalytic domain
GO:0033180	proton-transporting V-type ATPase, V1 domain
GO:0042470	melanosome
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000194 ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain
IPR000793 ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal
IPR004100 ATPase, F1 complex alpha/beta subunit, N-terminal domain
IPR005723 ATPase, V1 complex, subunit B
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00006
PF00306
PF02874

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P31408

PhosphoSite