InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ATP6V1B2

Summary

InnateDB Gene

IDBG-634398.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP6V1B2

Gene Name

V-type proton ATPase subunit B, brain isoform

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000018646

Encoded Proteins

IDBP-686215

V-type proton ATPase subunit B, brain isoform

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000147416:
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:67798291-67824441

Strand

Forward strand

Band

Transcripts

ENSBTAT00000024812

ENSBTAP00000024812

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.

Predicted by orthology
Total	45 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0015991	ATP hydrolysis coupled proton transport
GO:0015992	proton transport
GO:0046034	ATP metabolic process

Cellular Component

GO:0001726	ruffle
GO:0005737	cytoplasm
GO:0005765	lysosomal membrane
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005902	microvillus
GO:0012505	endomembrane system
GO:0016020	membrane
GO:0033178	proton-transporting two-sector ATPase complex, catalytic domain
GO:0033180	proton-transporting V-type ATPase, V1 domain
GO:0042470	melanosome
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome