InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: FLOT1

Summary

InnateDB Protein

IDBP-686299.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FLOT1

Protein Name

Flotillin-1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000013135

InnateDB Gene

IDBG-634509 (FLOT1)

Protein Structure

UniProt Annotation

Function

May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Membrane, caveola {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Melanosome {ECO:0000250}. Endosome {ECO:0000250}. Note=Membrane-associated protein of caveolae. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 77 interaction(s) predicted by orthology.

Predicted by orthology
Total	77 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0005515	protein binding

Biological Process

GO:0007409	axonogenesis
GO:0022617	extracellular matrix disassembly
GO:0035023	regulation of Rho protein signal transduction
GO:0072659	protein localization to plasma membrane
GO:0090002	establishment of protein localization to plasma membrane

Cellular Component

GO:0005765	lysosomal membrane
GO:0005768	endosome
GO:0005815	microtubule organizing center
GO:0005886	plasma membrane
GO:0005901	caveola
GO:0008180	COP9 signalosome
GO:0016020	membrane
GO:0016600	flotillin complex
GO:0034451	centriolar satellite
GO:0042383	sarcolemma
GO:0042470	melanosome
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome