Version 5.4
Bos taurus Gene: FLOT1
Summary
InnateDB Gene IDBG-634509.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FLOT1
Gene Name Flotillin-1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000009960
Encoded Proteins
IDBP-686299
Flotillin-1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137312:
Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. FLOT1 encodes a caveolae-associated, integral membrane protein. The function of flotillin 1 has not been determined. [provided by RefSeq, Jul 2008]
Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. FLOT1 encodes a caveolae-associated, integral membrane protein. The function of flotillin 1 has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 23:28090029-28100113
Strand Forward strand
Band
Transcripts
ENSBTAT00000013135 ENSBTAP00000013135
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 77 interaction(s) predicted by orthology.
Predicted by orthology
Total 77 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0005515 protein binding
Biological Process
GO:0007409 axonogenesis
GO:0022617 extracellular matrix disassembly
GO:0035023 regulation of Rho protein signal transduction
GO:0072659 protein localization to plasma membrane
GO:0090002 establishment of protein localization to plasma membrane
Cellular Component
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0005815 microtubule organizing center
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0008180 COP9 signalosome
GO:0016020 membrane
GO:0016600 flotillin complex
GO:0034451 centriolar satellite
GO:0042383 sarcolemma
GO:0042470 melanosome
GO:0045121 membrane raft
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000137312
View Gene Order
ENSMUSG00000059714
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
hsa04910
Insulin signaling pathway pathway
mmu04910
Insulin signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt Q08DN8
TrEMBL Q3MHZ0
UniProt Splice Variant
Entrez Gene 532573
UniGene Bt.26845
RefSeq NM_001076887
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC104516 BC123642
GenPept AAI04517 AAI23643
RNA Seq Atlas 532573

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca