InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: TP73

Summary

InnateDB Protein

IDBP-686356.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TP73

Protein Name

tumor protein p73

Synonyms

TP73;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000007643

InnateDB Gene

IDBG-634515 (TP73)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 99 interaction(s) predicted by orthology.

Predicted by orthology
Total	99 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019901	protein kinase binding
GO:0042802	identical protein binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0001836	release of cytochrome c from mitochondria
GO:0006355	regulation of transcription, DNA-templated
GO:0006915	apoptotic process
GO:0006954	inflammatory response
GO:0006974	cellular response to DNA damage stimulus
GO:0007050	cell cycle arrest
GO:0009791	post-embryonic development
GO:0021766	hippocampus development
GO:0030900	forebrain development
GO:0033326	cerebrospinal fluid secretion
GO:0043508	negative regulation of JUN kinase activity
GO:0043523	regulation of neuron apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0045793	positive regulation of cell size
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048546	digestive tract morphogenesis
GO:0048666	neuron development
GO:0051262	protein tetramerization
GO:1902167	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:2001235	positive regulation of apoptotic signaling pathway

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR001660 Sterile alpha motif domain
IPR002117 p53 tumour suppressor family
IPR008967 p53-like transcription factor, DNA-binding
IPR010991 p53, tetramerisation domain
IPR011510 Sterile alpha motif, type 2
IPR011615 p53, DNA-binding domain
IPR013761 Sterile alpha motif/pointed domain

PFAM

PF07710
PF07647
PF00870

PRINTS

PR00386

PIRSF

SMART

SM00454

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt