InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: TP73

Summary

InnateDB Gene

IDBG-634515.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TP73

Gene Name

Uncharacterized protein

Synonyms

TP73

Species

Bos taurus

Ensembl Gene

ENSBTAG00000005812

Encoded Proteins

IDBP-686356

tumor protein p73

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 22976836

[Homo sapiens] TP73 is required for macrophage-mediated innate immunity and the resolution of inflammatory responses. (Demonstrated in mouse)

PMID 22976836

[Mus musculus] Trp73 is required for macrophage-mediated innate immunity and the resolution of inflammatory responses.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000078900:
This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:50596706-50646330

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000007643

ENSBTAP00000007643

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 99 interaction(s) predicted by orthology.

Predicted by orthology
Total	99 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019901	protein kinase binding
GO:0042802	identical protein binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0001836	release of cytochrome c from mitochondria
GO:0006355	regulation of transcription, DNA-templated
GO:0006915	apoptotic process
GO:0006954	inflammatory response
GO:0006974	cellular response to DNA damage stimulus
GO:0007050	cell cycle arrest
GO:0009791	post-embryonic development
GO:0021766	hippocampus development
GO:0030900	forebrain development
GO:0033326	cerebrospinal fluid secretion
GO:0043508	negative regulation of JUN kinase activity
GO:0043523	regulation of neuron apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0045793	positive regulation of cell size
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048546	digestive tract morphogenesis
GO:0048666	neuron development
GO:0051262	protein tetramerization
GO:1902167	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:2001235	positive regulation of apoptotic signaling pathway