Version 5.4
Bos taurus Protein: GABARAP
Summary
InnateDB Protein IDBP-686439.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GABARAP
Protein Name Gamma-aminobutyric acid receptor-associated protein
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000019814
InnateDB Gene IDBG-634658 (GABARAP)
Protein Structure
UniProt Annotation
Function Ubiquitin-like modifier that play a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity). {ECO:0000250}.
Subcellular Localization Endomembrane system {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}. Cytoplasmic vesicle, autophagosome {ECO:0000250}. Note=Largely associated with intracellular membrane structures including the Golgi apparatus and postsynaptic cisternae. Colocalizes with microtubules (By similarity). Localizes also to discrete punctae along the ciliary axoneme (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 76 interaction(s) predicted by orthology.
Predicted by orthology
Total 76 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0048487 beta-tubulin binding
GO:0050811 GABA receptor binding
Biological Process
GO:0000045 autophagic vacuole assembly
GO:0000226 microtubule cytoskeleton organization
GO:0006810 transport
GO:0006914 autophagy
GO:0006915 apoptotic process
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0015031 protein transport
Cellular Component
GO:0000139 Golgi membrane
GO:0000421 autophagic vacuole membrane
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005776 autophagic vacuole
GO:0005790 smooth endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0005875 microtubule associated complex
GO:0005886 plasma membrane
GO:0005930 axoneme
GO:0012505 endomembrane system
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0031410 cytoplasmic vesicle
Protein Structure and Domains
PDB ID
InterPro IPR004241 Autophagy protein Atg8 ubiquitin like
IPR007242 Ubiquitin-like protein Atg12
IPR029071 Ubiquitin-related domain
PFAM PF02991
PF04110
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9GJW7
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 327715
UniGene Bt.49217
RefSeq NP_001029220
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AJ297742 BC103060
GenPept AAI03061 CAC12804

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca